Preparation of Bis (β-chloroethyl) sulfide (I)
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منابع مشابه
Reaction of Enzymes and Proteins with Mustard Gas (bis(β-chloroethyl)sulfide)
1. The rate of reaction of mustard gas (H) with thirteen proteins has been determined. The extreme variation in reaction rates is about 100:1. 2. No qualitative difference in the results was observed when the treatment with H was carried out by the Dixon or stirring methods. 3. The kinetics have been analyzed and a bimolecular equation derived which fits the facts. 4. The carboxyl groups of all...
متن کاملSolubility of Mustard Gas [bis (β-chloroethyl) Sulfide] in Water, Molar Sodium Chloride, and in Solutions of Detergents
1. The solubility of mustard (H) in water and in molar sodium chloride was found to be 5.8 x 10(-3) molar and 3.2 x 10(-3) molar respectively or 0.92 mg. per ml. and 0.5 mg. per ml. Solubility curves have been drawn and the usefulness of this method in examining the homogeneity of H preparations as well as in establishing their solubility, is discussed. 2. Certain detergents increase the solubi...
متن کاملGenomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure.
Bis-(2-chloroethyl) sulfide (sulfur mustard, SM) is a carcinogenic alkylating agent that has been utilized as a chemical warfare agent. To understand the mechanism of SM-induced lung injury, we analyzed global changes in gene expression in a rat lung SM exposure model. Rats were injected in the femoral vein with liquid SM, which circulates directly to the pulmonary vein and then to the lung. Ra...
متن کاملInhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
ICR/Ha Swiss mice, 30 females/group, were given a single application of 20 mug 7,12-dimethylbenz(a)anthracene, followed 2 weeks later by three times weekly applications of phorbol myristate acetate (PMA), 2.5 mug/application. In the accompanying inhibition experiments, sulfur mustard [SM; bis(2-chloroethyl)sulfide] was applied at a dose of 20 mug/application during the promotion phase, either o...
متن کاملPREPARATION AND MOLECULAR STRUCTURE OF BIS (TETRAMETHYLETHYLENEDIAMINE) COPPER(I) DICHLORO CUPRATE(I) , [Cu (TMEDA) ] [CuC1 ]
A complex of N, N, N', N', -tetramethylated ethylenediamine, TMEDA, with CuCI is prepared. The crystal and molecular structure of this complex is characterized by a single-crystal X-ray diffraction study. The complex is found to contain [Cu (TMEDA) ] cation which is nearly tetrahedral and the [CuCI ) anion is linear which Cu lies on a center of symmetry. Crystals are monoclinic space grou...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1955
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.13.367